Prof Ammar Al-Chalabi

Consultant Neurologist

Year Qualified: 1989
Qualifications: MB ChB, PhD, FRCP, DipStat
Specialty: Neurology

Special Interests

Amyotrophic lateral sclerosis
complex disease genetics
epidemiology
Motor neurone disease

Biography

Professor of Neurology and Complex Disease Genetics, Consultant Neurologist.
Director King’s MND Care and Research Centre, and King’s Motor Nerve Clinic, Clinical Scientist at King’s College London, Maurice Wohl Clinical Neuroscience Institute.

For more information see about Professor Al-Chalabi’s work see:

publications
research (below)
his video interview about Motor neurone disease(also known as ALS)

Related services

Research

Brown RH Jr, Al-Chalabi A (2015) ‘Endogenous retroviruses in ALS: A reawakening?‘, Science translational medicine, 7,(307):307fs40
Al-Chalabi A, Pearce N (2015) ‘Commentary: Mapping the Human Exposome: Without It, How Can We Find Environmental Risk Factors for ALS?‘, Epidemiology (Cambridge, Mass.), 26,(6):821-3
Wong CH, Topp S, Gkazi AS, Troakes C, Miller JW, de Majo M, Kirby J, Shaw PJ, Morrison KE, de Belleroche J, Vance CA, Al-Chalabi A, Al-Sarraj S, Shaw CE, Smith BN (2015) ‘The CHCHD10 P34S variant is not associated with ALS in a UK cohort of familial and sporadic patients‘, Neurobiology of aging, 36,(10):2908.e17-8
Watermeyer TJ, Brown RG, Sidle KC, Oliver DJ, Allen C, Karlsson J, Ellis C, Shaw CE, Al-Chalabi A, Goldstein LH (2015) ‘Impact of disease, cognitive and behavioural factors on caregiver outcome in amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 16,(5-6):316-23
Gould RL, Coulson MC, Brown RG, Goldstein LH, Al-Chalabi A, Howard RJ (2015) ‘Psychotherapy and pharmacotherapy interventions to reduce distress or improve well-being in people with amyotrophic lateral sclerosis: A systematic review‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 16,(5-6):293-302
Smith L, Cupid BC, Dickie BG, Al-Chalabi A, Morrison KE, Shaw CE, Shaw PJ (2015) ‘Establishing the UK DNA Bank for motor neuron disease (MND)‘, BMC genetics, 16,():84
van der Kleij LA, Jones AR, Steen IN, Young CA, Shaw PJ, Shaw CE, Leigh PN, Turner MR, Al-Chalabi A (2015) ‘Regionality of disease progression predicts prognosis in amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, ():1-6
Watermeyer TJ, Brown RG, Sidle KC, Oliver DJ, Allen C, Karlsson J, Ellis CM, Shaw CE, Al-Chalabi A, Goldstein LH (2015) ‘Executive dysfunction predicts social cognition impairment in amyotrophic lateral sclerosis‘, Journal of neurology, 262,(7):1681-90
Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E, SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CA, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L (2015) ‘The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease‘, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, ():
Martin NH, Lawrence V, Murray J, Janssen A, Higginson I, Lyall R, Burman R, Leigh PN, Al-Chalabi A, Goldstein LH (2015) ‘Decision Making About Gastrostomy and Noninvasive Ventilation in Amyotrophic Lateral Sclerosis‘, Qualitative health research, ():
Jones AR, Troakes C, King A, Sahni V, De Jong S, Bossers K, Papouli E, Mirza M, Al-Sarraj S, Shaw CE, Shaw PJ, Kirby J, Veldink JH, Macklis JD, Powell JF, Al-Chalabi A (2015) ‘Stratified gene expression analysis identifies major amyotrophic lateral sclerosis genes‘, Neurobiology of aging, 36,(5):2006.e1-9
Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JM, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A, FALS Sequencing Consortium, Al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, Van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB (2015) ‘Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways‘, Science (New York, N.Y.), 347,(6229):1436-41
Greenaway LP, Martin NH, Lawrence V, Janssen A, Al-Chalabi A, Leigh PN, Goldstein LH (2015) ‘Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients’ perspectives‘, Journal of neurology, 262,(4):1002-13
Morgan S, Shoai M, Fratta P, Sidle K, Orrell R, Sweeney MG, Shatunov A, Sproviero W, Jones A, Al-Chalabi A, Malaspina A, Houlden H, Hardy J, Pittman A (2015) ‘Investigation of next-generation sequencing technologies as a diagnostic tool for amyotrophic lateral sclerosis‘, Neurobiology of aging, 36,(3):1600.e5-8
Smith BN, Vance C, Scotter EL, Troakes C, Wong CH, Topp S, Maekawa S, King A, Mitchell JC, Lund K, Al-Chalabi A, Ticozzi N, Silani V, Sapp P, Brown RH Jr, Landers JE, Al-Sarraj S, Shaw CE (2015) ‘Novel mutations support a role for Profilin 1 in the pathogenesis of ALS‘, Neurobiology of aging, 36,(3):1602.e17-27
Agosta F, Al-Chalabi A, Filippi M, Hardiman O, Kaji R, Meininger V, Nakano I, Shaw P, Shefner J, van den Berg LH, Ludolph A, WFN Research Group on ALS/MND (2015) ‘The El Escorial criteria: strengths and weaknesses‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 16,(1-2):1-7
Beer AM, Cooper-Knock J, Higginbottom A, Highley JR, Wharton SB, Ince PG, Milano A, Jones AA, Al-Chalabi A, Kirby J, Shaw PJ (2015) ‘Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 16,(3-4):249-51
Balendra R, Jones A, Jivraj N, Steen IN, Young CA, Shaw PJ, Turner MR, Leigh PN, Al-Chalabi A, UK-MND LiCALS Study Group, Mito Target ALS Study Group (2015) ‘Use of clinical staging in amyotrophic lateral sclerosis for phase 3 clinical trials‘, Journal of neurology, neurosurgery, and psychiatry, 86,(1):45-9
Fogh I, Al-Chalabi A, Powell J (2014) ‘Heritability of amyotrophic lateral sclerosis‘, JAMA neurology, 71,(12):1579-80
Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp S, Kenna KP, Scotter EL, Kost J, Keagle P, Miller JW, Calini D, Vance C, Danielson EW, Troakes C, Tiloca C, Al-Sarraj S, Lewis EA, King A, Colombrita C, Pensato V, Castellotti B, de Belleroche J, Baas F, ten Asbroek AL, Sapp PC, McKenna-Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Pérez J, Muñoz-Blanco JL, Simpson M, SLAGEN Consortium, van Rheenen W, Diekstra FP, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Sorarù G, Morrison KE, Williams KL, Nicholson GA, Blair IP, Dion PA, Leblond CS, Rouleau GA, Hardiman O, Veldink JH, van den Berg LH, Al-Chalabi A, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, García-Redondo A, Wu Z, Glass JD, Gellera C, Ratti A, Brown RH Jr, Silani V, Shaw CE, Landers JE (2014) ‘Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS‘, Neuron, 84,(2):324-31
Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, Scott KM, Scotton WJ, Seelen M, Shaw CE, Sidle KS, Swingler R, Tsuda M, Veldink JH, Visser AE, van den Berg LH, Pearce N (2014) ‘Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study‘, The Lancet. Neurology, 13,(11):1108-13
Simon NG, Turner MR, Vucic S, Al-Chalabi A, Shefner J, Lomen-Hoerth C, Kiernan MC (2014) ‘Quantifying disease progression in amyotrophic lateral sclerosis‘, Annals of neurology, 76,(5):643-57
Wallace VC, Ellis CM, Burman R, Knights C, Shaw CE, Al-Chalabi A (2014) ‘The evaluation of pain in amyotrophic lateral sclerosis: a case controlled observational study‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 15,(7-8):520-7
Al-Chalabi A, Visscher PM (2014) ‘Motor neuron disease: Common genetic variants and the heritability of ALS‘, Nature reviews. Neurology, 10,(10):549-50
Diekstra FP, Van Deerlin VM, van Swieten JC, Al-Chalabi A, Ludolph AC, Weishaupt JH, Hardiman O, Landers JE, Brown RH Jr, van Es MA, Pasterkamp RJ, Koppers M, Andersen PM, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, van Damme P, Melki J, Meininger V, Shatunov A, Shaw CE, Leigh PN, Shaw PJ, Morrison KE, Fogh I, Chiò A, Traynor BJ, Czell D, Weber M, Heutink P, de Bakker PI, Silani V, Robberecht W, van den Berg LH, Veldink JH (2014) ‘C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis‘, Annals of neurology, 76,(1):120-33
Keren N, Scott KM, Tsuda M, Barnwell J, Knibb JA, Ellis CM, Leigh PN, Shaw CE, Al-Chalabi A (2014) ‘Evidence of an environmental effect on survival in ALS‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 15,(7-8):528-33
van Doormaal PT, Ticozzi N, Gellera C, Ratti A, Taroni F, Chiò A, Calvo A, Mora G, Restagno G, Traynor BJ, Birve A, Lemmens R, van Es MA, Saris CG, Blauw HM, van Vught PW, Groen EJ, Corrado L, Mazzini L, Del Bo R, Corti S, Waibel S, Meyer T, Ludolph AC, Goris A, van Damme P, Robberecht W, Shatunov A, Fogh I, Andersen PM, D’Alfonso S, Hardiman O, Cronin S, Rujescu D, Al-Chalabi A, Landers JE, Silani V, van den Berg LH, Veldink JH (2014) ‘Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study‘, Neurobiology of aging, 35,(10):2420.e13-4
Balendra R, Jones A, Jivraj N, Knights C, Ellis CM, Burman R, Turner MR, Leigh PN, Shaw CE, Al-Chalabi A (2014) ‘Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 15,(3-4):279-84
Jones AR, Jivraj N, Balendra R, Murphy C, Kelly J, Thornhill M, Young C, Shaw PJ, Leigh PN, Turner MR, Steen IN, McCrone P, Al-Chalabi A (2014) ‘Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 15,(3-4):285-91
Savage AL, Wilm TP, Khursheed K, Shatunov A, Morrison KE, Shaw PJ, Shaw CE, Smith B, Breen G, Al-Chalabi A, Moss D, Bubb VJ, Quinn JP (2014) ‘An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS‘, PloS one, 9,(6):e90833
Martin NH, Landau S, Janssen A, Lyall R, Higginson I, Burman R, McCrone P, Sakel M, Ellis CM, Shaw CE, Al-Chalabi A, Leigh PN, Goldstein LH (2014) ‘Psychological as well as illness factors influence acceptance of non-invasive ventilation (NIV) and gastrostomy in amyotrophic lateral sclerosis (ALS): a prospective population study‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 15,(5-6):376-87
Al-Chalabi A (2014) ‘High-calorie diets in amyotrophic lateral sclerosis‘, Lancet (London, England), 383,(9934):2028-30
Fahey C, Byrne S, McLaughlin R, Kenna K, Shatunov A, Donohoe G, Gill M, Al-Chalabi A, Bradley DG, Hardiman O, Corvin AP, Morris DW (2014) ‘Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample‘, Neurobiology of aging, 35,(6):1510.e1-5
Fogh I, Ratti A, Gellera C, Lin K, Tiloca C, Moskvina V, Corrado L, Sorarù G, Cereda C, Corti S, Gentilini D, Calini D, Castellotti B, Mazzini L, Querin G, Gagliardi S, Del Bo R, Conforti FL, Siciliano G, Inghilleri M, Saccà F, Bongioanni P, Penco S, Corbo M, Sorbi S, Filosto M, Ferlini A, Di Blasio AM, Signorini S, Shatunov A, Jones A, Shaw PJ, Morrison KE, Farmer AE, Van Damme P, Robberecht W, Chiò A, Traynor BJ, Sendtner M, Melki J, Meininger V, Hardiman O, Andersen PM, Leigh NP, Glass JD, Overste D, Diekstra FP, Veldink JH, van Es MA, Shaw CE, Weale ME, Lewis CM, Williams J, Brown RH, Landers JE, Ticozzi N, Ceroni M, Pegoraro E, Comi GP, D’Alfonso S, van den Berg LH, Taroni F, Al-Chalabi A, Powell J, Silani V, SLAGEN Consortium and Collaborators (2014) ‘A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis‘, Human molecular genetics, 23,(8):2220-31
Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ, International Multiple Sclerosis Genetics Consortium, van Es M, Australia and New Zealand MS Genetics Consortium, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH Jr, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg JR, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI (2014) ‘No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis‘, Human molecular genetics, 23,(7):1916-22
Al-Chalabi A, Hardiman O (2013) ‘The epidemiology of ALS: a conspiracy of genes, environment and time‘, Nature reviews. Neurology, 9,(11):617-28
Staats KA, Van Helleputte L, Jones AR, Bento-Abreu A, Van Hoecke A, Shatunov A, Simpson CL, Lemmens R, Jaspers T, Fukami K, Nakamura Y, Brown RH Jr, Van Damme P, Liston A, Robberecht W, Al-Chalabi A, Van Den Bosch L (2013) ‘Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice‘, Neurobiology of disease, 60,():11-7
Byrne S, Heverin M, Elamin M, Bede P, Lynch C, Kenna K, MacLaughlin R, Walsh C, Al Chalabi A, Hardiman O (2013) ‘Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis‘, Annals of neurology, 74,(5):699-708
Abel O, Powell JF, Andersen PM, Al-Chalabi A (2013) ‘Credibility analysis of putative disease-causing genes using bioinformatics‘, PloS one, 8,(6):e64899
Sherman AV, Gubitz AK, Al-Chalabi A, Bedlack R, Berry J, Conwit R, Harris BT, Horton DK, Kaufmann P, Leitner ML, Miller R, Shefner J, Vonsattel JP, Mitsumoto H (2013) ‘Infrastructure resources for clinical research in amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 14 Suppl 1,():53-61
Al-Chalabi A, Kwak S, Mehler M, Rouleau G, Siddique T, Strong M, Leigh PN (2013) ‘Genetic and epigenetic studies of amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 14 Suppl 1,():44-52
Factor-Litvak P, Al-Chalabi A, Ascherio A, Bradley W, Chío A, Garruto R, Hardiman O, Kamel F, Kasarskis E, McKee A, Nakano I, Nelson LM, Eisen A (2013) ‘Current pathways for epidemiological research in amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 14 Suppl 1,():33-43
Hobson EV, McGeachan A, Al-Chalabi A, Chandran S, Crawley F, Dick D, Donaghy C, Ealing J, Ellis CM, Gorrie G, Hanemann CO, Harrower T, Jung A, Majeed T, Malaspina A, Morrison K, Orrell RW, Pall H, Pinto A, Talbot K, Turner MR, Williams TL, Young CA, Shaw PJ, McDermott CJ (2013) ‘Management of sialorrhoea in motor neuron disease: a survey of current UK practice‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 14,(7-8):521-7
Deng M, Wei L, Zuo X, Tian Y, Xie F, Hu P, Zhu C, Yu F, Meng Y, Wang H, Zhang F, Ma H, Ye R, Cheng H, Du J, Dong W, Zhou S, Wang C, Wang Y, Wang J, Chen X, Sun Z, Zhou N, Jiang Y, Liu X, Li X, Zhang N, Liu N, Guan Y, Han Y, Han Y, Lv X, Fu Y, Yu H, Xi C, Xie D, Zhao Q, Xie P, Wang X, Zhang Z, Shen L, Cui Y, Yin X, Cheng H, Liang B, Zheng X, Lee TM, Chen G, Zhou F, Veldink JH, Robberecht W, Landers JE, Andersen PM, Al-Chalabi A, Shaw C, Liu C, Tang B, Xiao S, Robertson J, Zhang F, van den Berg LH, Sun L, Liu J, Yang S, Ju X, Wang K, Zhang X (2013) ‘Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis‘, Nature genetics, 45,(6):697-700
Mok K, Laaksovirta H, Tienari PJ, Peuralinna T, Myllykangas L, Chiò A, Traynor BJ, Nalls MA, Gurunlian N, Shatunov A, Restagno G, Mora G, Nigel Leigh P, Shaw CE, Morrison KE, Shaw PJ, Al-Chalabi A, Hardy J, Orrell RW (2013) ‘Homozygosity analysis in amyotrophic lateral sclerosis‘, European journal of human genetics : EJHG, 21,(12):1429-35
Jones AR, Woollacott I, Shatunov A, Cooper-Knock J, Buchman V, Sproviero W, Smith B, Scott KM, Balendra R, Abel O, McGuffin P, Ellis CM, Shaw PJ, Morrison KE, Farmer A, Lewis CM, Leigh PN, Shaw CE, Powell JF, Al-Chalabi A (2013) ‘Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat‘, Neurobiology of aging, 34,(9):2234.e1-7
Fang F, Al-Chalabi A, Ronnevi LO, Turner MR, Wirdefeldt K, Kamel F, Ye W (2013) ‘Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden‘, Amyotrophic lateral sclerosis & frontotemporal degeneration, 14,(5-6):362-8
UKMND-LiCALS Study Group, Morrison KE, Dhariwal S, Hornabrook R, Savage L, Burn DJ, Khoo TK, Kelly J, Murphy CL, Al-Chalabi A, Dougherty A, Leigh PN, Wijesekera L, Thornhill M, Ellis CM, O’Hanlon K, Panicker J, Pate L, Ray P, Wyatt L, Young CA, Copeland L, Ealing J, Hamdalla H, Leroi I, Murphy C, O’Keeffe F, Oughton E, Partington L, Paterson P, Rog D, Sathish A, Sexton D, Smith J, Vanek H, Dodds S, Williams TL, Steen IN, Clarke J, Eziefula C, Howard R, Orrell R, Sidle K, Sylvester R, Barrett W, Merritt C, Talbot K, Turner MR, Whatley C, Williams C, Williams J, Cosby C, Hanemann CO, Iman I, Philips C, Timings L, Crawford SE, Hewamadduma C, Hibberd R, Hollinger H, McDermott C, Mils G, Rafiq M, Shaw PJ, Taylor A, Waines E, Walsh T, Addison-Jones R, Birt J, Hare M, Majid T (2013) ‘Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial‘, The Lancet. Neurology, 12,(4):339-45
Diaper DC, Adachi Y, Sutcliffe B, Humphrey DM, Elliott CJ, Stepto A, Ludlow ZN, Vanden Broeck L, Callaerts P, Dermaut B, Al-Chalabi A, Shaw CE, Robinson IM, Hirth F (2013) ‘Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes‘, Human molecular genetics, 22,(8):1539-57
Abel O, Shatunov A, Jones AR, Andersen PM, Powell JF, Al-Chalabi A (2013) ‘Development of a Smartphone App for a Genetics Website: The Amyotrophic Lateral Sclerosis Online Genetics Database (ALSoD)‘, JMIR mHealth and uHealth, 1,(2):e18
Ruffell TO, Martin NH, Janssen A, Wijesekera L, Knights C, Burman R, Oliver DJ, Al-Chalabi A, Goldstein LH (2013) ‘Healthcare professionals’ views on the provision of gastrostomy and noninvasive ventilation to amyotrophic lateral sclerosis patients in England, Wales, and Northern Ireland‘, Journal of palliative care, 29,(4):225-31
van Rheenen W, Diekstra FP, van Doormaal PT, Seelen M, Kenna K, McLaughlin R, Shatunov A, Czell D, van Es MA, van Vught PW, van Damme P, Smith BN, Waibel S, Schelhaas HJ, van der Kooi AJ, de Visser M, Weber M, Robberecht W, Hardiman O, Shaw PJ, Shaw CE, Morrison KE, Al-Chalabi A, Andersen PM, Ludolph AC, Veldink JH, van den Berg LH (2013) ‘H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis‘, Neurobiology of aging, 34,(5):1517.e5-7
Taylor LJ, Brown RG, Tsermentseli S, Al-Chalabi A, Shaw CE, Ellis CM, Leigh PN, Goldstein LH (2013) ‘Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?‘, Journal of neurology, neurosurgery, and psychiatry, 84,(5):494-8
Ahmeti KB, Ajroud-Driss S, Al-Chalabi A, Andersen PM, Armstrong J, Birve A, Blauw HM, Brown RH, Bruijn L, Chen W, Chio A, Comeau MC, Cronin S, Diekstra FP, Soraya Gkazi A, Glass JD, Grab JD, Groen EJ, Haines JL, Hardiman O, Heller S, Huang J, Hung WY, ITALSGEN consortium, Jaworski JM, Jones A, Khan H, Landers JE, Langefeld CD, Leigh PN, Marion MC, McLaughlin RL, Meininger V, Melki J, Miller JW, Mora G, Pericak-Vance MA, Rampersaud E, Robberecht W, Russell LP, Salachas F, Saris CG, Shatunov A, Shaw CE, Siddique N, Siddique T, Smith BN, Sufit R, Topp S, Traynor BJ, Vance C, van Damme P, van den Berg LH, van Es MA, van Vught PW, Veldink JH, Yang Y, Zheng JG, ALSGEN Consortium (2013) ‘Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1‘, Neurobiology of aging, 34,(1):357.e7-19
Smith BN, Newhouse S, Shatunov A, Vance C, Topp S, Johnson L, Miller J, Lee Y, Troakes C, Scott KM, Jones A, Gray I, Wright J, Hortobágyi T, Al-Sarraj S, Rogelj B, Powell J, Lupton M, Lovestone S, Sapp PC, Weber M, Nestor PJ, Schelhaas HJ, Asbroek AA, Silani V, Gellera C, Taroni F, Ticozzi N, Van den Berg L, Veldink J, Van Damme P, Robberecht W, Shaw PJ, Kirby J, Pall H, Morrison KE, Morris A, de Belleroche J, Vianney de Jong JM, Baas F, Andersen PM, Landers J, Brown RH Jr, Weale ME, Al-Chalabi A, Shaw CE (2013) ‘The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder‘, European journal of human genetics : EJHG, 21,(1):102-8
Vyas NS, Lee Y, Ahn K, Ternouth A, Stahl DR, Al-Chalabi A, Powell JF, Puri BK (2012) ‘Association of a Serotonin Receptor 2A Gene Polymorphism with Visual Sustained Attention in Early-Onset Schizophrenia Patients and their Non-Psychotic Siblings‘, Aging and disease, 3,(4):291-300
Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, Veldink JH, Hardiman O, Van Den Bosch L, Gonzalez-Perez P, Van Damme P, Brown RH Jr, van den Berg LH, Robberecht W (2012) ‘EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans‘, Nature medicine, 18,(9):1418-22
Al-Chalabi A, Jones A, Troakes C, King A, Al-Sarraj S, van den Berg LH (2012) ‘The genetics and neuropathology of amyotrophic lateral sclerosis‘, Acta neuropathologica, 124,(3):339-52
Johnson L, Miller JW, Gkazi AS, Vance C, Topp SD, Newhouse SJ, Al-Chalabi A, Smith BN, Shaw CE (2012) ‘Screening for OPTN mutations in a cohort of British amyotrophic lateral sclerosis patients‘, Neurobiology of aging, 33,(12):2948.e15-7
Johnson J, Leigh PN, Shaw CE, Ellis C, Burman R, Al-Chalabi A (2012) ‘Eating-derived pleasure in amyotrophic lateral sclerosis as a predictor of non-oral feeding‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 13,(6):555-9
Miller JW, Smith BN, Topp SD, Al-Chalabi A, Shaw CE, Vance C (2012) ‘Mutation analysis of VCP in British familial and sporadic amyotrophic lateral sclerosis patients‘, Neurobiology of aging, 33,(11):2721.e1-2
Abel O, Powell JF, Andersen PM, Al-Chalabi A (2012) ‘ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics‘, Human mutation, 33,(9):1345-51
Scotton WJ, Scott KM, Moore DH, Almedom L, Wijesekera LC, Janssen A, Nigro C, Sakel M, Leigh PN, Shaw C, Al-Chalabi A (2012) ‘Prognostic categories for amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 13,(6):502-8
Turner MR, Barnwell J, Al-Chalabi A, Eisen A (2012) ‘Young-onset amyotrophic lateral sclerosis: historical and other observations‘, Brain : a journal of neurology, 135,(Pt 9):2883-91
Diekstra FP, Saris CG, van Rheenen W, Franke L, Jansen RC, van Es MA, van Vught PW, Blauw HM, Groen EJ, Horvath S, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Robberecht W, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH Jr, Shatunov A, Shaw CE, Leigh PN, Al-Chalabi A, Ophoff RA, van den Berg LH, Veldink JH (2012) ‘Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS‘, PloS one, 7,(4):e35333
Pedroso I, Lourdusamy A, Rietschel M, Nöthen MM, Cichon S, McGuffin P, Al-Chalabi A, Barnes MR, Breen G (2012) ‘Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes‘, Biological psychiatry, 72,(4):311-7
Byrne S, Elamin M, Bede P, Shatunov A, Walsh C, Corr B, Heverin M, Jordan N, Kenna K, Lynch C, McLaughlin RL, Iyer PM, O’Brien C, Phukan J, Wynne B, Bokde AL, Bradley DG, Pender N, Al-Chalabi A, Hardiman O (2012) ‘Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study‘, The Lancet. Neurology, 11,(3):232-40
Roche JC, Rojas-Garcia R, Scott KM, Scotton W, Ellis CE, Burman R, Wijesekera L, Turner MR, Leigh PN, Shaw CE, Al-Chalabi A (2012) ‘A proposed staging system for amyotrophic lateral sclerosis‘, Brain : a journal of neurology, 135,(Pt 3):847-52
Rojas-Garcia R, Scott KM, Roche JC, Scotton W, Martin N, Janssen A, Goldstein LH, Leigh PN, Ellis CM, Shaw CE, Al-Chalabi A (2012) ‘No evidence for a large difference in ALS frequency in populations of African and European origin: a population based study in inner city London‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 13,(1):66-8
Troakes C, Maekawa S, Wijesekera L, Rogelj B, Siklós L, Bell C, Smith B, Newhouse S, Vance C, Johnson L, Hortobágyi T, Shatunov A, Al-Chalabi A, Leigh N, Shaw CE, King A, Al-Sarraj S (2012) ‘An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline‘, Neuropathology : official journal of the Japanese Society of Neuropathology, 32,(5):505-14
Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Kölsch H, Heun R, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Davies G, Harris SE, Starr JM, Deary IJ, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Jones L, Holmans PA, O’Donovan MC, Owen MJ, Williams J (2012) ‘The role of variation at AßPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer’s disease‘, Journal of Alzheimer’s disease : JAD, 28,(2):377-87
Mok K, Traynor BJ, Schymick J, Tienari PJ, Laaksovirta H, Peuralinna T, Myllykangas L, Chiò A, Shatunov A, Boeve BF, Boxer AL, DeJesus-Hernandez M, Mackenzie IR, Waite A, Williams N, Morris HR, Simón-Sánchez J, van Swieten JC, Heutink P, Restagno G, Mora G, Morrison KE, Shaw PJ, Rollinson PS, Al-Chalabi A, Rademakers R, Pickering-Brown S, Orrell RW, Nalls MA, Hardy J (2012) ‘Chromosome 9 ALS and FTD locus is probably derived from a single founder‘, Neurobiology of aging, 33,(1):209.e3-8
Bogaert E, Goris A, Van Damme P, Geelen V, Lemmens R, van Es MA, van den Berg LH, Sleegers K, Verpoorten N, Timmerman V, De Jonghe P, Van Broeckhoven C, Traynor BJ, Landers JE, Brown RH Jr, Glass JD, Al-Chalabi A, Shaw CE, Birve A, Andersen PM, Slowik A, Tomik B, Melki J, Robberecht W, Van Den Bosch L (2012) ‘Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis‘, Neurobiology of aging, 33,(2):418-20
Fang F, Chen H, Wirdefeldt K, Ronnevi LO, Al-Chalabi A, Peters TL, Kamel F, Ye W (2011) ‘Infection of the central nervous system, sepsis and amyotrophic lateral sclerosis‘, PloS one, 6,(12):e29749
Al-Sarraj S, King A, Troakes C, Smith B, Maekawa S, Bodi I, Rogelj B, Al-Chalabi A, Hortobágyi T, Shaw CE (2011) ‘p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS‘, Acta neuropathologica, 122,(6):691-702
Andersen PM, Al-Chalabi A (2011) ‘Clinical genetics of amyotrophic lateral sclerosis: what do we really know?‘, Nature reviews. Neurology, 7,(11):603-15
Al-Chalabi A, Shaw PJ, Young CA, Morrison KE, Murphy C, Thornhill M, Kelly J, Steen IN, Leigh PN, UKMND-LiCALS (2011) ‘Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31]‘, BMC neurology, 11,():111
Hanby MF, Scott KM, Scotton W, Wijesekera L, Mole T, Ellis CE, Leigh PN, Shaw CE, Al-Chalabi A (2011) ‘The risk to relatives of patients with sporadic amyotrophic lateral sclerosis‘, Brain : a journal of neurology, 134,(Pt 12):3454-7
Al-Chalabi A, Lewis CM (2011) ‘Modelling the effects of penetrance and family size on rates of sporadic and familial disease‘, Human heredity, 71,(4):281-8
Turner MR, Wicks P, Brownstein CA, Massagli MP, Toronjo M, Talbot K, Al-Chalabi A (2011) ‘Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis‘, Journal of neurology, neurosurgery, and psychiatry, 82,(8):853-4
Fogh I, D’Alfonso S, Gellera C, Ratti A, Cereda C, Penco S, Corrado L, Sorarù G, Castellotti B, Tiloca C, Gagliardi S, Cozzi L, Lupton MK, Ticozzi N, Mazzini L, Shaw CE, Al-Chalabi A, Powell J, Silani V (2011) ‘No association of DPP6 with amyotrophic lateral sclerosis in an Italian population‘, Neurobiology of aging, 32,(5):966-7
Lill CM, Abel O, Bertram L, Al-Chalabi A (2011) ‘Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 12,(4):238-49
Vivekananda U, Manjalay ZR, Ganesalingam J, Simms J, Shaw CE, Leigh PN, Turner MR, Al-Chalabi A (2011) ‘Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability‘, Journal of neurology, neurosurgery, and psychiatry, 82,(6):635-7
Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE, Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chiò A, Traynor BJ, Melki J, Meininger V, Landers JE, McGuffin P, Glass JD, Pall H, Leigh PN, Hardy J, Brown RH Jr, Powell JF, Orrell RW, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A (2010) ‘Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study‘, The Lancet. Neurology, 9,(10):986-94
Blauw HM, Al-Chalabi A, Andersen PM, van Vught PW, Diekstra FP, van Es MA, Saris CG, Groen EJ, van Rheenen W, Koppers M, Van’t Slot R, Strengman E, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Kiemeney LA, Vermeulen SH, Birve A, Waibel S, Meyer T, Cronin S, McLaughlin RL, Hardiman O, Sapp PC, Tobin MD, Wain LV, Tomik B, Slowik A, Lemmens R, Rujescu D, Schulte C, Gasser T, Brown RH Jr, Landers JE, Robberecht W, Ludolph AC, Ophoff RA, Veldink JH, van den Berg LH (2010) ‘A large genome scan for rare CNVs in amyotrophic lateral sclerosis‘, Human molecular genetics, 19,(20):4091-9
Taes I, Goris A, Lemmens R, van Es MA, van den Berg LH, Chio A, Traynor BJ, Birve A, Andersen P, Slowik A, Tomik B, Brown RH Jr, Shaw CE, Al-Chalabi A, Boonen S, Van Den Bosch L, Dubois B, Van Damme P, Robberecht W (2010) ‘Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse‘, Neurology, 74,(21):1687-93
Rio A, Ellis C, Shaw C, Willey E, Ampong MA, Wijesekera L, Rittman T, Nigel Leigh P, Sidhu PS, Al-Chalabi A (2010) ‘Nutritional factors associated with survival following enteral tube feeding in patients with motor neurone disease‘, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 23,(4):408-15
Scott KM, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein LH, Janssen A, Dougherty A, Willey E, Stanton BR, Turner MR, Ampong MA, Sakel M, Orrell R, Howard R, Shaw CE, Nigel Leigh P, Al-Chalabi A (2010) ‘The association between ALS and population density: A population based study‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 11,(5):435-8
Lemmens R, Moore MJ, Al-Chalabi A, Brown RH Jr, Robberecht W (2010) ‘RNA metabolism and the pathogenesis of motor neuron diseases‘, Trends in neurosciences, 33,(5):249-58
Manjaly ZR, Scott KM, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein LH, Janssen A, Dougherty A, Willey E, Stanton BR, Turner MR, Ampong MA, Sakel M, Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A (2010) ‘The sex ratio in amyotrophic lateral sclerosis: A population based study‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 11,(5):439-42
Al-Chalabi A, Fang F, Hanby MF, Leigh PN, Shaw CE, Ye W, Rijsdijk F (2010) ‘An estimate of amyotrophic lateral sclerosis heritability using twin data‘, Journal of neurology, neurosurgery, and psychiatry, 81,(12):1324-6
Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O’Donovan MC, Owen MJ, Williams J (2010) ‘Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease‘, PloS one, 5,(11):e13950
Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A (2009) ‘Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration‘, Human molecular genetics, 18,(3):472-81
Lambrechts D, Poesen K, Fernández-Santiago R, Al-Chalabi A, Del Bo R, Van Vught PW, Khan S, Marklund SL, Brockington A, van Marion I, Anneser J, Shaw C, Ludolph AC, Leigh NP, Comi GP, Gasser T, Shaw PJ, Morrison KE, Andersen PM, Van den Berg LH, Thijs V, Siddique T, Robberecht W, Carmeliet P (2009) ‘Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype‘, Journal of medical genetics, 46,(12):840-6
Al-Chalabi A (2009) ‘Genome-wide association studies‘, Cold Spring Harbor protocols, 2009,(12):pdb.top66
Wain LV, Pedroso I, Landers JE, Breen G, Shaw CE, Leigh PN, Brown RH, Tobin MD, Al-Chalabi A (2009) ‘The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci‘, PloS one, 4,(12):e8175
Al-Chalabi A, Dürr A, Wood NW, Parkinson MH, Camuzat A, Hulot JS, Morrison KE, Renton A, Sussmuth SD, Landwehrmeyer BG, Ludolph A, Agid Y, Brice A, Leigh PN, Bensimon G, NNIPPS Genetic Study Group (2009) ‘Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy‘, PloS one, 4,(9):e7114
Ganesalingam J, Stahl D, Wijesekera L, Galtrey C, Shaw CE, Leigh PN, Al-Chalabi A (2009) ‘Latent cluster analysis of ALS phenotypes identifies prognostically differing groups‘, PloS one, 4,(9):e7107
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O’Donovan M, Owen MJ, Williams J (2009) ‘Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease‘, Nature genetics, 41,(10):1088-93
van Es MA, Veldink JH, Saris CG, Blauw HM, van Vught PW, Birve A, Lemmens R, Schelhaas HJ, Groen EJ, Huisman MH, van der Kooi AJ, de Visser M, Dahlberg C, Estrada K, Rivadeneira F, Hofman A, Zwarts MJ, van Doormaal PT, Rujescu D, Strengman E, Giegling I, Muglia P, Tomik B, Slowik A, Uitterlinden AG, Hendrich C, Waibel S, Meyer T, Ludolph AC, Glass JD, Purcell S, Cichon S, Nöthen MM, Wichmann HE, Schreiber S, Vermeulen SH, Kiemeney LA, Wokke JH, Cronin S, McLaughlin RL, Hardiman O, Fumoto K, Pasterkamp RJ, Meininger V, Melki J, Leigh PN, Shaw CE, Landers JE, Al-Chalabi A, Brown RH Jr, Robberecht W, Andersen PM, Ophoff RA, van den Berg LH (2009) ‘Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis‘, Nature genetics, 41,(10):1083-7
Sabatelli M, Eusebi F, Al-Chalabi A, Conte A, Madia F, Luigetti M, Mancuso I, Limatola C, Trettel F, Sobrero F, Di Angelantonio S, Grassi F, Di Castro A, Moriconi C, Fucile S, Lattante S, Marangi G, Murdolo M, Orteschi D, Del Grande A, Tonali P, Neri G, Zollino M (2009) ‘Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis‘, Human molecular genetics, 18,(20):3997-4006
Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM, Broom WJ, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink JH, Ivinson AJ, Saris CG, Hosler BA, Barnes-Nessa A, Couture N, Wokke JH, Kwiatkowski TJ Jr, Ophoff RA, Cronin S, Hardiman O, Diekstra FP, Leigh PN, Shaw CE, Simpson CL, Hansen VK, Powell JF, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz HR, Lathrop M, Purcell S, Al-Chalabi A, Brown RH Jr (2009) ‘Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis‘, Proceedings of the National Academy of Sciences of the United States of America, 106,(22):9004-9
Butler AW, Ng MY, Hamshere ML, Forabosco P, Wroe R, Al-Chalabi A, Lewis CM, Powell JF (2009) ‘Meta-analysis of linkage studies for Alzheimer’s disease–a web resource‘, Neurobiology of aging, 30,(7):1037-47
Wills AM, Cronin S, Slowik A, Kasperaviciute D, Van Es MA, Morahan JM, Valdmanis PN, Meininger V, Melki J, Shaw CE, Rouleau GA, Fisher EM, Shaw PJ, Morrison KE, Pamphlett R, Van den Berg LH, Figlewicz DA, Andersen PM, Al-Chalabi A, Hardiman O, Purcell S, Landers JE, Brown RH Jr (2009) ‘A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS‘, Neurology, 73,(1):16-24
Wijesekera LC, Mathers S, Talman P, Galtrey C, Parkinson MH, Ganesalingam J, Willey E, Ampong MA, Ellis CM, Shaw CE, Al-Chalabi A, Leigh PN (2009) ‘Natural history and clinical features of the flail arm and flail leg ALS variants‘, Neurology, 72,(12):1087-94
Wicks P, Abrahams S, Papps B, Al-Chalabi A, Shaw CE, Leigh PN, Goldstein LH (2009) ‘SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis‘, Journal of neurology, 256,(2):234-41
Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE (2009) ‘Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6‘, Science (New York, N.Y.), 323,(5918):1208-11
Lewis D, Ampong MA, Rio A, Willey E, Johnson J, Shaw CE, Ellis CM, Al-Chalabi A, Leigh PN, Sidhu PS (2009) ‘Mushroom-cage gastrostomy tube placement in patients with amyotrophic lateral sclerosis: a 5-year experience in 104 patients in a single institution‘, European radiology, 19,(7):1763-71
Beleza-Meireles A, Al-Chalabi A (2009) ‘Genetic studies of amyotrophic lateral sclerosis: controversies and perspectives‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 10,(1):1-14
Diekstra FP, Beleza-Meireles A, Leigh NP, Shaw CE, Al-Chalabi A (2009) ‘Interaction between PON1 and population density in amyotrophic lateral sclerosis‘, Neuroreport, 20,(2):186-90
Hindocha N, Nabbout R, Elmslie F, Makoff A, Al-Chalabi A, Nashef L (2009) ‘A case report of a family with overlapping features of autosomal dominant febrile seizures and GEFS+‘, Epilepsia, 50,(4):937-42
Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, Sakel M, Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A (2009) ‘Geographical clustering of amyotrophic lateral sclerosis in South-East England: a population study‘, Neuroepidemiology, 32,(2):81-8
Landers JE, Shi L, Cho TJ, Glass JD, Shaw CE, Leigh PN, Diekstra F, Polak M, Rodriguez-Leyva I, Niemann S, Traynor BJ, McKenna-Yasek D, Sapp PC, Al-Chalabi A, Wills AM, Brown RH Jr (2008) ‘A common haplotype within the PON1 promoter region is associated with sporadic ALS‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 9,(5):306-14
Wroe R, Wai-Ling Butler A, Andersen PM, Powell JF, Al-Chalabi A (2008) ‘ALSOD: the Amyotrophic Lateral Sclerosis Online Database‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 9,(4):249-50
van de Giessen E, Fogh I, Gopinath S, Smith B, Hu X, Powell J, Andersen P, Nicholson G, Al Chalabi A, Shaw CE (2008) ‘Association study on glutathione S-transferase omega 1 and 2 and familial ALS‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 9,(2):81-4
Landers JE, Leclerc AL, Shi L, Virkud A, Cho T, Maxwell MM, Henry AF, Polak M, Glass JD, Kwiatkowski TJ, Al-Chalabi A, Shaw CE, Leigh PN, Rodriguez-Leyza I, McKenna-Yasek D, Sapp PC, Brown RH Jr (2008) ‘New VAPB deletion variant and exclusion of VAPB mutations in familial ALS‘, Neurology, 70,(14):1179-85
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, Baralle F, de Belleroche J, Mitchell JD, Leigh PN, Al-Chalabi A, Miller CC, Nicholson G, Shaw CE (2008) ‘TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis‘, Science (New York, N.Y.), 319,(5870):1668-72
Tripathi VB, Al-Chalabi A (2008) ‘Molecular insights and therapeutic targets in amyotrophic lateral sclerosis‘, CNS & neurological disorders drug targets, 7,(1):11-9
Hindocha N, Nashef L, Elmslie F, Birch R, Zuberi S, Al-Chalabi A, Crotti L, Schwartz PJ, Makoff A (2008) ‘Two cases of sudden unexpected death in epilepsy in a GEFS+ family with an SCN1A mutation‘, Epilepsia, 49,(2):360-5
McCormick AL, Brown RH Jr, Cudkowicz ME, Al-Chalabi A, Garson JA (2008) ‘Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate‘, Neurology, 70,(4):278-83
Vivekananda U, Johnston C, McKenna-Yasek D, Shaw CE, Leigh PN, Brown RH, Al-Chalabi A (2008) ‘Birth order and the genetics of amyotrophic lateral sclerosis‘, Journal of neurology, 255,(1):99-102
Broom WJ, Johnson DV, Auwarter KE, Iafrate AJ, Russ C, Al-Chalabi A, Sapp PC, McKenna-Yasek D, Andersen PM, Brown RH Jr (2008) ‘SOD1A4V-mediated ALS: absence of a closely linked modifier gene and origination in Asia‘, Neuroscience letters, 430,(3):241-5
Turner MR, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, Leigh PN (2007) ‘Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET‘, Journal of neurology, 254,(8):1033-6
Abhinav K, Al-Chalabi A, Hortobagyi T, Leigh PN (2007) ‘Electrical injury and amyotrophic lateral sclerosis: a systematic review of the literature‘, Journal of neurology, neurosurgery, and psychiatry, 78,(5):450-3
Shaw CE, Arechavala-Gomeza V, Al-Chalabi A (2007) ‘Chapter 14 Familial amyotrophic lateral sclerosis‘, Handbook of clinical neurology, 82,():279-300
Beghi E, Mennini T, Bendotti C, Bigini P, Logroscino G, Chiò A, Hardiman O, Mitchell D, Swingler R, Traynor BJ, Al-Chalabi A (2007) ‘The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure‘, Current medicinal chemistry, 14,(30):3185-200
Turner MR, Hammers A, Allsop J, Al-Chalabi A, Shaw CE, Brooks DJ, Leigh PN, Andersen PM (2007) ‘Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 8,(6):343-7
Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell RW, Howard R, Clarke J, Sakel M, Ampong MA, Shaw CE, Leigh PN, Al-Chalabi A (2007) ‘Amyotrophic lateral sclerosis in South-East England: a population-based study. The South-East England register for amyotrophic lateral sclerosis (SEALS Registry)‘, Neuroepidemiology, 29,(1-2):44-8
Al-Chalabi A (2007) ‘The multidisciplinary clinic, quality of life and survival in motor neuron disease‘, Journal of neurology, 254,(8):1118
Isaacs JD, Dean AF, Shaw CE, Al-Chalabi A, Mills KR, Leigh PN (2007) ‘Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?‘, Journal of neurology, neurosurgery, and psychiatry, 78,(7):750-3
Fogh I, Rijsdijk F, Andersen PM, Sham PC, Knight J, Neale B, McKenna-Yasek D, Silani V, Brown RH Jr, Powell JF, Al-Chalabi A (2007) ‘Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality‘, Neurogenetics, 8,(3):235-6
Wicks P, Ganesalingham J, Collin C, Prevett M, Leigh NP, Al-Chalabi A (2007) ‘Three soccer playing friends with simultaneous amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 8,(3):177-9
Kasperaviciute D, Weale ME, Shianna KV, Banks GT, Simpson CL, Hansen VK, Turner MR, Shaw CE, Al-Chalabi A, Pall HS, Goodall EF, Morrison KE, Orrell RW, Beck M, Jablonka S, Sendtner M, Brockington A, Ince PG, Hartley J, Nixon H, Shaw PJ, Schiavo G, Wood NW, Goldstein DB, Fisher EM (2007) ‘Large-scale pathways-based association study in amyotrophic lateral sclerosis‘, Brain : a journal of neurology, 130,(Pt 9):2292-301
Turner MR, Rabiner EA, Al-Chalabi A, Shaw CE, Brooks DJ, Leigh PN, Andersen PM (2007) ‘Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS‘, Neurology, 68,(15):1233-5
Johnston CA, Stanton BR, Turner MR, Gray R, Blunt AH, Butt D, Ampong MA, Shaw CE, Leigh PN, Al-Chalabi A (2006) ‘Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London‘, Journal of neurology, 253,(12):1642-3
Simpson CL, Al-Chalabi A (2006) ‘Amyotrophic lateral sclerosis as a complex genetic disease‘, Biochimica et biophysica acta, 1762,(11-12):973-85
Shaw CE, Al-Chalabi A (2006) ‘Susceptibility genes in sporadic ALS: separating the wheat from the chaff by international collaboration‘, Neurology, 67,(5):738-9
Shaw AS, Ampong MA, Rio A, Al-Chalabi A, Sellars ME, Ellis C, Shaw CE, Leigh NP, Sidhu PS (2006) ‘Survival of patients with ALS following institution of enteral feeding is related to pre-procedure oximetry: a retrospective review of 98 patients in a single centre‘, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 7,(1):16-21
Vance C, Al-Chalabi A, Ruddy D, Smith BN, Hu X, Sreedharan J, Siddique T, Schelhaas HJ, Kusters B, Troost D, Baas F, de Jong V, Shaw CE (2006) ‘Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3‘, Brain : a journal of neurology, 129,(Pt 4):868-76
Morita M, Al-Chalabi A, Andersen PM, Hosler B, Sapp P, Englund E, Mitchell JE, Habgood JJ, de Belleroche J, Xi J, Jongjaroenprasert W, Horvitz HR, Gunnarsson LG, Brown RH Jr (2006) ‘A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia‘, Neurology, 66,(6):839-44
Nishimura AL, Al-Chalabi A, Zatz M (2005) ‘A common founder for amyotrophic lateral sclerosis type 8 (ALS8) in the Brazilian population‘, Human genetics, 118,(3-4):499-500
Rio A, Ampong MA, Turner MR, Shaw AS, Al-Chalabi A, Shaw CE, Leigh PN, Sidhu PS (2005) ‘Comparison of two percutaneous radiological gastrostomy tubes in the nutritional management of ALS patients‘, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 6,(3):177-81
Turner MR, Osei-Lah AD, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, Leigh PN, Mills KR (2005) ‘Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS‘, Journal of neurology, neurosurgery, and psychiatry, 76,(9):1279-85
Turner MR, Gerhard A, Al-Chalabi A, Shaw CE, Hughes RA, Banati RB, Brooks DJ, Leigh PN (2005) ‘Mills’ and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET‘, Journal of neurology, neurosurgery, and psychiatry, 76,(6):871-4
Turner MR, Hammers A, Al-Chalabi A, Shaw CE, Andersen PM, Brooks DJ, Leigh PN (2005) ‘Distinct cerebral lesions in sporadic and ‘D90A’ SOD1 ALS: studies with [11C]flumazenil PET‘, Brain : a journal of neurology, 128,(Pt 6):1323-9
Meaburn E, Butcher LM, Liu L, Fernandes C, Hansen V, Al-Chalabi A, Plomin R, Craig I, Schalkwyk LC (2005) ‘Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs‘, BMC genomics, 6,():52
Al-Chalabi A, Leigh PN (2005) ‘Trouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis?‘, Brain : a journal of neurology, 128,(Pt 3):451-3
Simpson CL, Knight J, Butcher LM, Hansen VK, Meaburn E, Schalkwyk LC, Craig IW, Powell JF, Sham PC, Al-Chalabi A (2005) ‘A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays‘, Nucleic acids research, 33,(3):e25
Steele AJ, Al-Chalabi A, Ferrante K, Cudkowicz ME, Brown RH Jr, Garson JA (2005) ‘Detection of serum reverse transcriptase activity in patients with ALS and unaffected blood relatives‘, Neurology, 64,(3):454-8
Turner MR, Rabiner EA, Hammers A, Al-Chalabi A, Grasby PM, Shaw CE, Brooks DJ, Leigh PN (2005) ‘[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS‘, Brain : a journal of neurology, 128,(Pt 4):896-905
Broom WJ, Parton MJ, Vance CA, Russ C, Andersen PM, Hansen V, Leigh PN, Powell JF, Al-Chalabi A, Shaw CE (2004) ‘No association of the SOD1 locus and disease susceptibility or phenotype in sporadic ALS‘, Neurology, 63,(12):2419-22
Simpson CL, Hansen VK, Sham PC, Collins A, Powell JF, Al-Chalabi A (2004) ‘MaGIC: a program to generate targeted marker sets for genome-wide association studies‘, BioTechniques, 37,(6):996-9
Butcher LM, Meaburn E, Liu L, Fernandes C, Hill L, Al-Chalabi A, Plomin R, Schalkwyk L, Craig IW (2004) ‘Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits‘, Behavior genetics, 34,(5):549-55
Leigh PN, Abrahams S, Al-Chalabi A, Ampong MA, Goldstein LH, Johnson J, Lyall R, Moxham J, Mustfa N, Rio A, Shaw C, Willey E, King’s MND Care and Research Team (2003) ‘The management of motor neurone disease‘, Journal of neurology, neurosurgery, and psychiatry, 74 Suppl 4,():iv32-iv47
Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P (2003) ‘VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death‘, Nature genetics, 34,(4):383-94
Ruddy DM, Parton MJ, Al-Chalabi A, Lewis CM, Vance C, Smith BN, Leigh PN, Powell JF, Siddique T, Meyjes EP, Baas F, de Jong V, Shaw CE (2003) ‘Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q‘, American journal of human genetics, 73,(2):390-6
Al-Chalabi A, Scheffler MD, Smith BN, Parton MJ, Cudkowicz ME, Andersen PM, Hayden DL, Hansen VK, Turner MR, Shaw CE, Leigh PN, Brown RH Jr (2003) ‘Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis‘, Annals of neurology, 54,(1):130-4
Turner MR, Parton MJ, Shaw CE, Leigh PN, Al-Chalabi A (2003) ‘Prolonged survival in motor neuron disease: a descriptive study of the King’s database 1990-2002‘, Journal of neurology, neurosurgery, and psychiatry, 74,(7):995-7
Al-Chalabi A, Hansen VK, Simpson CL, Xi J, Hosler BA, Powell JF, McKenna-Yasek D, Shaw CE, Leigh PN, Brown RH Jr (2003) ‘Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis‘, Neurogenetics, 4,(4):221-2
Al-Chalabi A, Miller CC (2003) ‘Neurofilaments and neurological disease‘, BioEssays : news and reviews in molecular, cellular and developmental biology, 25,(4):346-55
Turner M, Al-Chalabi A (2002) ‘Early symptom progression rate is related to ALS outcome: a prospective population-based study‘, Neurology, 59,(12):2012-3; author reply 2013
Parton MJ, Broom W, Andersen PM, Al-Chalabi A, Nigel Leigh P, Powell JF, Shaw CE, D90A SOD1 ALS Consortium (2002) ‘D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype‘, Human mutation, 20,(6):473
Turner MR, Bakker M, Sham P, Shaw CE, Leigh PN, Al-Chalabi A (2002) ‘Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis‘, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 3,(1):15-21
Shaw CE, al-Chalabi A, Leigh N (2001) ‘Progress in the pathogenesis of amyotrophic lateral sclerosis‘, Current neurology and neuroscience reports, 1,(1):69-76
Lloyd CM, Richardson MP, Brooks DJ, Al-Chalabi A, Leigh PN (2000) ‘Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil‘, Brain : a journal of neurology, 123 ( Pt 11),():2289-96
Al-Chalabi A, Leigh PN (2000) ‘Recent advances in amyotrophic lateral sclerosis‘, Current opinion in neurology, 13,(4):397-405
Andrews WD, Tuke PW, Al-Chalabi A, Gaudin P, Ijaz S, Parton MJ, Garson JA (2000) ‘Detection of reverse transcriptase activity in the serum of patients with motor neurone disease‘, Journal of medical virology, 61,(4):527-32
Al-Chalabi A, Andersen PM, Nilsson P, Chioza B, Andersson JL, Russ C, Shaw CE, Powell JF, Leigh PN (1999) ‘Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis‘, Human molecular genetics, 8,(2):157-64
Hu MT, Ellis CM, Al-Chalabi A, Leigh PN, Shaw CE (1998) ‘Flail arm syndrome: a distinctive variant of amyotrophic lateral sclerosis‘, Journal of neurology, neurosurgery, and psychiatry, 65,(6):950-1
Al-Chalabi A, Andersen PM, Chioza B, Shaw C, Sham PC, Robberecht W, Matthijs G, Camu W, Marklund SL, Forsgren L, Rouleau G, Laing NG, Hurse PV, Siddique T, Leigh PN, Powell JF (1998) ‘Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor‘, Human molecular genetics, 7,(13):2045-50
Shaw CE, Enayat ZE, Chioza BA, Al-Chalabi A, Radunovic A, Powell JF, Leigh PN (1998) ‘Mutations in all five exons of SOD-1 may cause ALS‘, Annals of neurology, 43,(3):390-4
Andrews WD, Al-Chalabi A, Garson JA (1997) ‘Lack of evidence for HTLV tax-rex DNA in motor neurone disease‘, Journal of the neurological sciences, 153,(1):86-90
al-Chalabi AS, Hawker D (1997) ‘Response of vehicular lead to the presence of street dust in the atmospheric environment of major roads‘, The Science of the total environment, 206,(2-3):195-202
Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE (1997) ‘Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation‘, Annals of neurology, 42,(5):803-7
Abrahams S, Goldstein LH, Al-Chalabi A, Pickering A, Morris RG, Passingham RE, Brooks DJ, Leigh PN (1997) ‘Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis‘, Journal of neurology, neurosurgery, and psychiatry, 62,(5):464-72
Hoda F, Nicholl D, Bennett P, Arranz M, Aitchison KJ, al-Chalabi A, Kunugi H, Vallada H, Leigh PN, Chaudhuri KR, Collier DA (1996) ‘No association between Parkinson’s disease and low-activity alleles of catechol O-methyltransferase‘, Biochemical and biophysical research communications, 228,(3):780-4
Jackson M, Morrison KE, Al-Chalabi A, Bakker M, Leigh PN (1996) ‘Analysis of chromosome 5q13 genes in amyotrophic lateral sclerosis: homozygous NAIP deletion in a sporadic case‘, Annals of neurology, 39,(6):796-800
al-Chalabi A, Enayat ZE, Bakker MC, Sham PC, Ball DM, Shaw CE, Lloyd CM, Powell JF, Leigh PN (1996) ‘Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron disease‘, Lancet (London, England), 347,(8995):159-60
al-Chalabi A, Abbott RJ (1995) ‘Angiotropic lymphoma in the differential diagnosis of systemic vasculitis‘, Journal of neurology, neurosurgery, and psychiatry, 59,(2):219
al-Chalabi A, Powell JF, Leigh PN (1995) ‘Neurofilaments, free radicals, excitotoxins, and amyotrophic lateral sclerosis‘, Muscle & nerve, 18,(5):540-5
al-Chalabi A, Sivakumaran M, Holton J, West KP, Wood JK, Abbott RJ (1994) ‘A case of intravascular malignant lymphomatosis (angiotropic lymphoma) with raised perinuclear antineutrophil cytoplasmic antibody titres–a hitherto unreported association‘, Clinical and laboratory haematology, 16,(4):363-9