100,000 Genomes Project


King’s is one of a select group of hospitals taking part in the national 100,000 Genomes Project. This involves collecting blood samples from certain patients and their relatives, to increase our understanding of certain cancers and rare diseases. We want as many King’s patients as possible to donate blood, to help us improve patient care through research.

A genome is the code in our DNA. It contains the information for about 20,000 genes. We all inherit a copy of the genome from each parent and it contains the information needed to make every part of the body. The small differences in genomes are what make us unique.

The 100,000 Genomes Project is being carried out on a scale not seen before anywhere else in the world. It aims to decode 100,000 human genomes in order to create a new genomic medicine service in the NHS, enhance our understanding of diseases and potentially change the way we treat patients.

Researchers are also studying how best to use genomics in healthcare and how best to interpret the data to help patients. The causes, diagnosis and treatment of disease are also being investigated. In some cases it might be possible to give patients a diagnosis where they didn’t have one before, and in the future, they may be offered more effective treatments.

Who can take part?

Patients with certain rare diseases, their close relatives, and patients with cancer are invited to take part. Visit the Genomics England website to check which rare diseases are included in the project.

How can I take part at King’s?

If you are a King’s patient who is eligible and you want to find out more, please telephone 020 3299 5748 or email: kch-tr.100k@nhs.net

Your healthcare team will discuss with you what will happen and the risks and benefits of participating, and you will be given information to read about the project. You are free to decide if you want to take part or not, and you can withdraw from the project at any time.

If you agree, we will take a sample of blood, which will be processed and analysed. Cancer patients will also have a tumour sample taken.

All patients and their relatives who agree to take part in the project will be required to sign a consent form.

Want to know more?

King’s is part of the South London NHS Genomic Medicine Centre - one of 13 centres nationally taking part in the project.

The project is being delivered in partnership with Genomics England and NHS England. Further information can be found on the Genomics England website.